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The supply chains of semiconductors and integrated devices supports industry across all economic sectors. Globally, the supply chain is experiencing a variety of stressors and disruptions, with effects that cascade across the economy, causing product delays and enterprise losses. However, quantitative models that support an understanding of how stressors influence supply chain performance are needed. Here we show how stress testing can be used for assessing the impact of disruptions on supply chain performance metrics and for characterizing system resilience. We demonstrate a framework that utilizes discrete event simulation for stress testing the resilience of a semiconductor supply chain. Our results include a comparison of resilience curves with and without risk management countermeasures, showing the resilience-enhancing benefits of various supply chain management strategies such as maintaining safety stock and sourcing from multiple suppliers. Supply chain managers can utilize stress testing principles and methodologies to configure their supply chain and engage in practices that contribute to system resilience.